The enlarged standard deduction means most filers come out ahead taking it. Itemizing only wins when your deductible costs — mortgage interest, SALT (capped), large charitable gifts, big medical bills — exceed it.
Bunching helps: shifting two years of charitable gifts into one tax year can push you over the threshold to itemize that year, then take the standard deduction the next.
Add up your itemizable costs and compare to the standard figure before assuming one or the other.